Comparison of analgesia effect between intravenous propacetamol and Tramadol

IV Acetaminophen [Propacetamol] is one the drugs which has recently been discussed in pain management. The Purpose of this study, is the comparison of analgesic effect of Propacetamol and Tramadol in pain relief of renal colic patients. This double blinded randomized clinical trial was preformed on 80 patients who came to ED of Hazrat Rasool Akram Hospital [HRAH] due to renal colic. Demographic data and pain scores were evaluated prior to injection [through numeric rating scale]. Then, patients received one of the drugs, drug A [1 gr Propacetamol] or B [100mg Tramadol] randomly. Pain relief and adverse effects of the drugs were evaluated 30 minutes after injection. After 1 hour satisfaction and the need to administer a narcotic were evaluated. Data was gathered and analyzed by T-test via SPSS software. The P value less than 0/05 was dertermined to be significant.The mean age in group A, was 33 +/- 8.6 yrs and in group B, was 34.2 +/- 8.2 yrs. Mean of pain score in group A, was 7.6 +/- 1.6 and in group B, was 7.5 +/- 15 Pain relief in group A, was 4.4 +/- 1.6 and in group B, was 2.6 +/- 1.2. Differences between the groups were significant. 12 cases [%30] in group A, and in 25 cases [%62/5] in group B, recieced additional analgesic for pain relief, thus, difference between groups was significant. According this study, IV Propacetamol is a safe and effective drug for pain relief in renal colic patients, without any significant adverse effects. Our survey showed that IV Propacetaimol is more efficient and has less side effects in comparison with Tramadol in the pain relief of renal colic patients

Comparative study of tramadol and propacetamol for postoperative pain management in patients undergoing nasal surgeries

To compare the analgesic and side effects of propacetamol and tramadol after nasal surgeries. King Abdul Aziz University Hospital, Riyadh [KSA]. From January 2006 to February 2007. A total number of 40 surgical patients were prospectively randomized into two equal groups of 20 and were entered into single blinded clinical trial. Anaethesta. protocol was similar for all patients. Pain intensity was measured based on a 4-point verbal rating scale [VRS]. VRS was obtained before analgesic administration [T0] and at 0.5, 1.5, 3, 4.5, 6, 12, 18 and 24 hours, Patients received either tramadol 100 mg I/V or propacetamol 2 gm I/V at T0 and then 50 mg tramadol or 1.5 gm propacetamol at 6, 12, 18 and 24 hours if pain was present. The results of this study showed that propacetamol is less effective as analgesic in severe pain requiring more supplementary morphine as compared to tramadol. On the other hand tramadol is associated with higher incidence of nausea and or vomiting than with parcetamol. It was concluded from the study that propacetamol is less effective as analgesic in severe pain receiving more supplementary morphine as compared to tramadol

Morphine sparing effect of proparacetamol in surgical and trauma intensive care

Safe and balanced analgesia is one of the corner stones in the management of critically ill patients. Patient controlled analgesia has proven to be one of the methods in achieving this goal. Combined analgesic regimes have been shown to improve pain therapy. The aim of our study is to evaluate efficacy and tolerability of morphine PCA, when used with mt ravenous proparacetamol in surgical and trauma intensive care patients. Forty-two patients were included in this prospective randomized study. Two patients were later excluded. Twenty patients received 2 grams proparacetamol every 6 hours and PCA morphine [proparacetamol and morphine group]. Another 20 patients received PCA morphine only [morphine group]. Each group had equal number of trauma and postoperative patients. Patients with head injury, liver trauma and allergy to paracetamol were excluded from the study. The total amount of morphine required for 24 hours and pain relief were evaluated. Tolerability was assessed by monitoring heart rate, blood pressure, respiratory rate, adverse effects, renal and hepatic parameters. The total morphine requirement in the proparacetamol and morphine group was significantly low [P<0.001]. Incidence of vomiting was also significantly lower in the proparacetamol and morphine group, this may be related to the amount of morphine consumption. There was no significant difference in renal and hepatic parameters. Using proparacetamol as adjuvant to patient controlled morphine analgesia, decreases total consumption and adverse effects of morphine in surgical and trauma intensive care patients

Propacetamol versus placebo for management of acute postoperative pain after elective tonsillectomy in children

The analgesic efficacy and safety of propacetamol, an injectabie prodrug of acetaminophen, was assessed versus placebo after elective tonsillectomy operation in children. Using a double-blind, randomized parallel group design, 70 children aged 6-12 years were included to evaluate the effect of a single iv infusion of 40 mg/kg propacetamol versus a single infusion of 100 ml normal saline [placebo] given at the recovery room. Analgesic efficacy was assessed on pain scores rated on a four-points verbal scale, a five-points visual scale [faces] and a four-points pain relief verbal scale; before administration [TO] and 0.25, 0.5, 1, 2, 3, 4, 5 and 6 hours after the infusion. The global efficacy was rated on a five-point scale at the end of the study. Rescue medication was allowed freely and the time for re-medication as well as the occurrence of any side effects was recorded. Propacetamol was statistically superior to placebo on all assessment criteria. The global final efficacy evaluation demonstrated 12 patients in the propacetamol group with good and very good scores compared to only one patient in the placebo group. Rescue medication was used in 40% of patients in the propacetamo! group versus 83% in the placebo group. No serious side effects were recorded in both groups and pain at the infusion arm was noticed in 4 patients with propacetamol and 2 patients in the placebo group [P> 0.05]. We concluded that, although propacetamol 40 mg/kg infusion may provide greater pain relief than placebo in children after tonsillectomy operation without any significant adverse effects, it is better to be used as a complementary drug to other analgesics in the treatment of moderate to severe postoperative pain